Journal of Heterocyclic Chemistry

The Behavior of 2??Substituted??3??hydroxyisoindolinones in the Reaction with sec??Butyllithium

A Jóźwiak, M Ciechańska

文献索引：Jozwiak; Ciechanska Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 2 p. 357 - 362

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被引用次数: 0

摘要

Abstract This paper presents a dualistic behavior of 2-substituted-3-hydroxyisoindolones in reactions with sec-butyllithium (sec-BuLi). 2-tert-Butyl-3-hydroxy-2, 3-dihydro-1H-isoindol-1- one (1a) treated with sec-BuLi undergoes metalation at position 7. On the other hand, the