Synthesis and Activity of Substituted Anthraquinones against a Human Filarial Parasite, Brugia m alayi

MR Dhananjeyan, YP Milev, MA Kron…

文献索引：Dhananjeyan, Mugunthu R.; Milev, Youli P.; Kron, Michael A.; Nair, Muraleedharan G. Journal of Medicinal Chemistry, 2005 , vol. 48, # 8 p. 2822 - 2830

全文：HTML全文

被引用次数: 52

摘要

Lymphatic filariasis (elephantiasis) is a global public health problem caused by the parasitic nematodes Wuchereria bancrofti and Brugia malayi. We have previously reported anthraquinones from daylily roots with potent activity against pathogenic trematode Schistosoma mansoni. Here we report the synthesis of novel anthraquinones AS and their antifilrarial activity. Anthraquinones AS were synthesized by a single-step Friedel-Crafts ...