The synthesis of fluoro (cyclo) alkylamines 1-amino-6-fluorohexane (1), 1-amino-7- fluoroheptane (2), cis/trans-4-fluorocyclohexylamine (3a, b) and cis-4- fluoromethylcyclohexylamine (4) has been investigated for use as synthons for histamine receptor ligands for use in PET.