Tetrahedron

Synthesis of substituted 4-(1H-indol-6-yl)-1H-indazoles as potential PDK1 inhibitors

M Brzozowski, NJ O'Brien, DJD Wilson, BM Abbott

文献索引：Brzozowski, Martin; O'Brien, Nathan J.; Wilson, David J.D.; Abbott, Belinda M. Tetrahedron, 2014 , vol. 70, # 2 p. 318 - 326

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被引用次数: 3

摘要

Abstract The development of a preparative route to a series of novel 4-(1H-indol-6-yl)-1H- indazole compounds as potential PDK1 inhibitors is described. The synthetic strategy centres on the late-stage Suzuki cross-coupling of N-unprotected indazole and indole fragments. The use of a monoligated palladium catalyst system was found to be highly beneficial in the cross-coupling reaction. The indazole and indole fragments were ...