[Use of 1- and 2-thionaphthylacetates as cholinesterase substrates].

Iu G Zhukovskiĭ, L P Kuznetsova, E E Sochilina, K V Veksler

文献索引：Ukr. Biokhim. Zh. 75(3) , 67-70, (2003)

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摘要

1- and 2-thionaphthylacetates were tested as cholinesterase substrates. It was shown that the butyrilcholinesterase from horse serum can hydrolize these compounds. The hydrolysis velocity of 1-thionaphthylacetate was comparable with hydrolysis velocity of acetylthiocholine (the well known cholinesterase substrate), but 2-thionaphthylacetate was hydrolysed more slowly. The values of the kinetic parameters V and K(m) for butyrylcholinesterase hydrolysis of 1- and 2-thionaphthylacetates were determined. It was offered to use 1-thionaphthylacetates as the substrate for cholinesterases.