Synthesis and pharmacological studies of 4, 4-disubstituted piperidines: a new class of compounds with potent analgesic properties

…, AM Ebnoether, E Rissi, F Gadient…

文献索引：Huegi, Bruno S.; Ebnoether, Anton M.; Rissi, Erwin; Gadient, Fulvio; Hauser, Daniel; et al. Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 42 - 50

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被引用次数: 14

摘要

CI R, substitution of the basic and nonbasic nitrogen of structure 7. The chemistry and structure-activity relationships of these derivatives are discussed in this paper. Chemistry. Two general synthetic routes were employed for the preparation of these piperidine analogues (Scheme I).(A) The primary approach involved the condensation of the commercially available l-benzyl-4-piperidinone 1 with the appropriate alkyl-, substituted ...