Tritylamino Aromatic Heterocycles and Related Carbinols as Blockers of Ca 2+??Activated Potassium Ion Channels Underlying Neuronal Hyperpolarization

…, Z Miscony, M Javadzadeh??Tabatabaie…

文献索引：Zunszain, Patricia A.; Shah, Mala M.; Miscony, Zena; Javadzadeh-Tabatabaie, Mazyar; Haylett, Dennis G.; Ganellin, C. Robin Archiv der Pharmazie, 2002 , vol. 335, # 4 p. 159 - 166

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被引用次数: 10

摘要

Abstract A series of novel aromatic tritylamino heterocycles has been synthesized and the compounds have been tested in comparison with clotrimazole for their ability to inhibit the slow afterhyperpolarization current (sI AHP) in cultured rat hippocampal pyramidal neurones. Some analogues of the clotrimazole metabolite, 2-chlorophenyl-diphenyl methanol, having different chlorination substitution in the triphenyl group have also been ...