Activation of the aryl hydrocarbon receptor by methyl yellow and related congeners: structure-activity relationships in halogenated derivatives.

…, T Matsuda, S Matsui, T Mizutani, K Saeki

文献索引：Kato, Taka-aki; Matsuda, Tomonari; Matsui, Saburo; Mizutani, Takaharu; Saeki, Ken-ichi Biological and pharmaceutical bulletin, 2002 , vol. 25, # 4 p. 466 - 471

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被引用次数: 19

摘要

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the biological action of many environmental compounds. Methyl yellow (4- dimethylaminoazobenzene; MY) is a principal azo-dye, and structurally related compounds were subjected to analysis of structure–activity relationships as AhR ligands by using a yeast AhR signaling assay. The effects of halogen-substitution among 23 halogenated ...