China Journal of Chinese Materia Medica 2006-10-01

[Advances in studies on pharmacokinetics of aristolochic acid I].

Guan Wang, Zhi-Min Wang, Qi-Shi Sun

文献索引：Zhongguo Zhong Yao Za Zhi 31(19) , 1573-5, (2006)

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摘要

Aristolochic acid I (AA-I) was absorbed and distributed quickly in vivo, the plasma concentration-time curve were fit with the open two-compartment model and one-compartment model, respectively. The elimination of AA-I has relationship with the dosage, the low dose group eliminates more quickly than the high dose group. The characters of pharmacokinetics of AA-I induce the cumulation of AA-I in vivo and the nephrotoxin to the kidney and other viscera.