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Organic Fluorine Compounds. III. Action of Perchloryl Fluoride on Substituted Ethyl Cyanoacetates and Animal Toxicities of the Fluorinated Products1-3

H Gershon, SG Schulman…

文献索引:Gershon,H. et al. Journal of Medicinal Chemistry, 1967 , vol. 10, p. 536 - 541

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被引用次数: 16

摘要

To overcome the disadvantages of a protonated solvent, the fluorination was conducted according to the method of Freeman." Ib was converted to Vb by formation of the potassio salt in the presence of potassium ethoxide, followed by displacement of the ethanol with dry dimethylformamide (DRIF) and fluorination with perchloryl fluoride. In addition to the expected elemental composition, the infrared spectrum of the product was characterized ...

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