Organoiodine (III) Mediated Synthesis of Novel Symmetrical Bis ([1, 2, 4] triazolo)[3, 4??a: 4′, 3′??c] phthalazines as Antibacterial and Antifungal Agents

…, DK Aneja, K Hussain, R Kumar, S Arora…

文献索引：Prakash, Om; Aneja, Deepak K.; Arora, Sanjiv; Hussain, Khalid; Kumar, Ravi; Sharma, Chetan; Aneja, Kamal R. Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 5 p. 1091 - 1097,7

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被引用次数: 7

摘要

Abstract A series of new symmetrical 3, 6-bis (aryl) bis ([1, 2, 4] triazolo)[3, 4-a: 4′, 3′-c] phthalazines 9a-l has been conveniently synthesized by oxidative cyclization of 1, 4-bis (substituted benzalhydrazino) phthalazines 8a-l promoted by iodobenzene diacetate under mild conditions (12 examples, up to 93% yield). All the 12 compounds were tested in vitro for their antibacterial activity against two Gram-positive bacteria, namely, Staphylococcus ...