Synthesis and antibacterial activity evaluation of metronidazole–triazole conjugates

N Kumar, RK Rohilla, N Roy, DS Rawat

文献索引：Beena; Kumar, Nitin; Rohilla, Rajesh K.; Roy; Rawat, Diwan S. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 5 p. 1396 - 1398

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被引用次数: 58

摘要

Synthesis and antibacterial activity of metronidazole–triazole conjugates are reported. Total 21 hybrid compounds have been synthesized with different substitution pattern on the triazole ring in order to study their influence on the antibacterial activity. These compounds demonstrated potent to weak antibacterial activity against Gram-positive, and Gram-negative bacteria. Six compounds have shown equal or better antibacterial activity against Gram- ...