Tetrahedron

4-Quinolylmethyl and 1-Naphthylmethyl as Benzyl-type Protecting Groups of Carboxylic Acids Removable by Homogeneous Palladium-Catalyzed Hydrogenolysis

A Boutros, JY Legros, JC Fiaud

文献索引：Boutros, Andre; Legros, Jean-Yves; Fiaud, Jean-Claude Tetrahedron, 2000 , vol. 56, # 15 p. 2239 - 2246

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被引用次数: 19

摘要

4-Quinolylmethyl (4-QUI) esters are reduced by palladium-catalyzed hydrogenolysis by formate anion. The reaction conditions are compatible with reducible substituents or functional groups as aromatic bromo, alkene, aldehyde, ketone, nitrile, ethyl and benzyl esters. An allyl ester is cleaved selectively in the presence of a 4-QUI ester. 1- Naphthylmethyl (1-NAP) esters of α-amino acids could be deprotected without any ...