The synthesis and biological evaluation of novel Danshensu–cysteine analog conjugates as cardiovascular-protective agents

…, P Zhou, X Liu, L Pan, H Xin, YZ Zhu, Y Wang

文献索引：Jia, Yaoling; Zhou, Pengfei; Wang, Yang; Dong, Xiaoyi; Liu, Xinhua; Pan, Lilong; Xin, Hong; Zhu, Yi Zhun European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 176 - 187,12

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被引用次数: 18

摘要

A series of novel amide and thioester conjugates between Danshensu and cysteine derivatives have been designed and synthesized based on the strategy of “medicinal chemical hybridization”. Pharmacological evaluation indicated that the amide conjugates 3a/4a/17a and thioester conjugates 6a–d exhibited obvious protective effects on H2O2- induced human umbilical vein endothelial cells (HUVECs). Pretreated with these ...