Antimicrobial Agents and Chemotherapy 2012-12-01

Stability of colistimethate sodium in aqueous solution.

A M Healan, W Gray, E J Fuchs, J M Griffiss, R A Salata, J Blumer

文献索引：J. Inorg. Biochem. 103(3) , 389-95, (2009)

全文：HTML全文

摘要

Colistimethate sodium, increasingly used to treat multidrug-resistant Gram-negative infections, spontaneously hydrolyzes to form colistin A (polymyxin E1) and B (polymyxin E2/B) when mixed with water. High levels of these active breakdown products at the time of administration have been associated with nephrotoxicity and even death. In this study, reconstituted colistimethate sodium was shown to be stable (<1.0% colistin A/B formation) for up to 24 h when stored at 21, 0, -20, and -70°C.