Bioorganic & Medicinal Chemistry Letters 2008-04-01

Fluorination of triptolide and its analogues and their cytotoxicity.

Yutaka Aoyagi, Yukio Hitotsuyanagi, Tomoyo Hasuda, Saki Matsuyama, Haruhiko Fukaya, Koichi Takeya, Ritsuo Aiyama, Takeshi Matsuzaki, Shusuke Hashimoto

文献索引：Bioorg. Med. Chem. Lett. 18(7) , 2459-63, (2008)

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摘要

The reaction of triptolide and its analogues with a fluorinating agent, that is, bis(2-methoxyethyl)aminosulfur trifluoride (Deoxo-Fluor) or (diethylamino)sulfur trifluoride (DAST), was studied. One of the fluorinated products, 14beta-dehydroxy-14beta-fluoro triptolide, was found to be more cytotoxic than the parent natural triptolide.