International journal of pancreatology : official journal of the International Association of Pancreatology 1991-09-01

Perspectives of CCK antagonists in pancreatic research. Part II. Experimental studies.

T Takács, A Pap

文献索引：Int. J. Pancreatol. 10(1) , 1-8, (1991)

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摘要

In this article, the effects of different classes of cholecystokinin (CCK) receptor antagonists in CCK-related physiological processes of the pancreas have been discussed. Both glutaramic acid derivatives and natural (benzodiazepine) analogs are potent, competitive antagonists of peripheral CCK receptors. These compounds thus provide a powerful tool for investigating the physiological and pharmacological actions of CCK in the gastrointestinal system, and have already clarified the role of CCK in pancreatic secretion and trophism or growth.