Journal of Organic Chemistry 2007-08-31

Highly atom efficient guanylation of both aromatic and secondary amines catalyzed by simple lanthanide amides.

Qinghai Li, Shaowu Wang, Shuangliu Zhou, Gaosheng Yang, Xiancui Zhu, Yuyu Liu

文献索引：J. Org. Chem. 72 , 6763, (2007)

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摘要

It is demonstrated that the cyclopentadienyl-free simple lanthanide amides [(Me(3)Si)(2)N](3)Ln(mu-Cl)Li(THF)(3)(Ln = La, Sm, Eu, Y, Yb) and Ln[N(SiMe(3))(2)]3 (Ln = Y, Yb) are highly efficient catalysts for the guanylation of both aromatic and secondary amines with a high activity under mild conditions. It is found that these catalysts are compatible with a wide range of solvents and substrates.