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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Tetrahedron

Studies of the reactions between indole-2, 3-diones (isatins) and 2-aminobenzylamine

J Bergman, R Engqvist, C Stålhandske, H Wallberg

文献索引：Bergman, Jan; Engqvist, Robert; Stalhandske, Claes; Wallberg, Hans Tetrahedron, 2003 , vol. 59, # 7 p. 1033 - 1048

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被引用次数: 96

摘要

Reflux of equimolecular amounts 2-aminobenzylamine and isatins in acetic acid produced indolo [3, 2-c] quinolin-6-ones in good yields. A proposed mechanism involving initial formation of a spiro compound is given. This isolable intermediate subsequently rearranges via a sequential isocyanate ring opening and a cyclisation process to a urea derivative which finally cyclized to the indolo [3, 2-c] quinolin-6-ones. The urea derivative could be ...

靛红结构式

邻苯二胺(OPD)结构式

邻苯二胺(OPD)

~80%

2(1H)-Quinoxalinone,3-(2-aminophenyl)结构式

2(1H)-Quinoxali...

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5-甲基靛红结构式

2-氨基苄胺结构式

~60%

2-methyl-5,11-dihydroindolo[3,2-c]quinolin-6-one结构式

2-methyl-5,11-d...

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1,2,3,4-tetrahydroquinazoline-5-methyl-2-spiro-3'-1H-indolin-2-one结构式

1,2,3,4-tetrahy...

~76%

2-methyl-5,11-dihydroindolo[3,2-c]quinolin-6-one结构式

2-methyl-5,11-d...

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氰化钠结构式

2-(2-amino-5-methylphenyl)-1H-indole结构式

2-(2-amino-5-me...

~71%

2-methyl-5,11-dihydroindolo[3,2-c]quinolin-6-one结构式

2-methyl-5,11-d...

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未登录结构式

~62%

2-methyl-5,11-dihydroindolo[3,2-c]quinolin-6-one结构式

2-methyl-5,11-d...

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Ethanone, 1-(2-amino-5-methylphenyl)- (9CI)结构式

Ethanone, 1-(2-...

~%

2-methyl-5,11-dihydroindolo[3,2-c]quinolin-6-one结构式

2-methyl-5,11-d...

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5-甲基靛红结构式

~%

2-methyl-5,11-dihydroindolo[3,2-c]quinolin-6-one结构式

2-methyl-5,11-d...

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2-氨基苄胺结构式

~%

2-methyl-5,11-dihydroindolo[3,2-c]quinolin-6-one结构式

2-methyl-5,11-d...

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2-(2-amino-5-methylphenyl)-1H-indole结构式

2-(2-amino-5-me...

~%

2-methyl-5,11-dihydroindolo[3,2-c]quinolin-6-one结构式

2-methyl-5,11-d...

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11-chloro-6H-indolo[2,3-b]quinoline结构式

11-chloro-6H-in...

~90%

11H-10,11-二氮杂苯并[b]芴结构式

11H-10,11-二氮杂苯并[b]芴

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3-吲哚甲酸甲酯结构式

3-吲哚甲酸甲酯

~%

11H-10,11-二氮杂苯并[b]芴结构式

11H-10,11-二氮杂苯并[b]芴

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2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~%

11H-10,11-二氮杂苯并[b]芴结构式

11H-10,11-二氮杂苯并[b]芴

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5,6-dihydro-11H-indolo[2,3-b]quinolin-11-one结构式

5,6-dihydro-11H...

~%

11H-10,11-二氮杂苯并[b]芴结构式

11H-10,11-二氮杂苯并[b]芴

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未登录结构式

~%

11H-10,11-二氮杂苯并[b]芴结构式

11H-10,11-二氮杂苯并[b]芴

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11-chloro-5-acetylindolo[2,3-b]quinoline结构式

11-chloro-5-ace...

~%

11H-10,11-二氮杂苯并[b]芴结构式

11H-10,11-二氮杂苯并[b]芴

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1-甲基靛红结构式

2-氨基苄胺结构式

~81%

5-methyl-11H-indolo[3,2-c]quinolin-6-one结构式

5-methyl-11H-in...

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2-氨基苄胺结构式

~%

5-methyl-11H-indolo[3,2-c]quinolin-6-one结构式

5-methyl-11H-in...

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5-甲基靛红结构式

~%

5-methyl-11H-indolo[3,2-c]quinolin-6-one结构式

5-methyl-11H-in...

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靛红结构式

2-氨基苄胺结构式

~95%

5,11-dihydro-6H-indolo[3,2-c]quinolin-6-one结构式

5,11-dihydro-6H...

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1,2,3,4-tetrahydroquinazoline-2-spiro-3'-1H-indolin-2-one结构式

1,2,3,4-tetrahy...

~97%

5,11-dihydro-6H-indolo[3,2-c]quinolin-6-one结构式

5,11-dihydro-6H...

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2-(2-氨基苯基)吲哚结构式

2-(2-氨基苯基)吲哚

氰化钠结构式

~79%

5,11-dihydro-6H-indolo[3,2-c]quinolin-6-one结构式

5,11-dihydro-6H...

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undec-4-yn-1-ol结构式

undec-4-yn-1-ol

~70%

5,11-dihydro-6H-indolo[3,2-c]quinolin-6-one结构式

5,11-dihydro-6H...

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