Biotransformation of organic sulfides. Part 12. Conversion of heterocyclic sulfides to chiral sulfoxides by Helminthosporium sp. NRRL 4671 and Mortierella isabellina …

…, CD Turner, PR Andreana, D Nguyen

文献索引：Holland, Herbert L.; Turner, Carl D.; Andreana, Peter R.; Nguyen, Doan Canadian Journal of Chemistry, 1999 , vol. 77, # 4 p. 463 - 471

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被引用次数: 19

摘要

The enantioselective oxidation of a series of heterocyclic prochiral sulfides to chiral sulfoxides has been examined using the fungal biocatalysts Helminthosporium species NRRL 4671 and Mortierella isabellina ATCC 42613. Methylthiofuranyl and-thiophenyl substrates gave (S)-configuration products in low to moderate enantiomeric purity on biotransformation with H. species, but pyridyl sulfides with the nitrogen atom located at an ...