Palladium-catalyzed coupling reactions of uracil nucleosides and nucleotides

CF Bigge, P Kalaritis, JR Deck…

文献索引：Bigge,C.F.; Kalaritis,P.; Deck,J.R. Journal of the American Chemical Society, 1980 , vol. 102, p. 2033

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被引用次数: 61

摘要

Abstract: A new method is described for the facile alkylation of uracil nucleotides. Treatment of the unprotected nucleotide with mercuric acetate followed by the addition of styrene or ring-substituted styrenes and lithium tetrachloropalladate affords the C-5-trans-styryl derivatives. The coupling reactions using nucleosides or nucleotides proceed in moderate to good yield, can be run in protic solvents, are not adversely affected by the presence of the ...