前往化源商城

Journal of Natural Products 1998-06-26

Synthesis and dopamine receptor selectivity of the benzyltetrahydroisoquinoline, (R)-(+)-nor-roefractine.

N Cabedo, P Protais, B K Cassels, D Cortes

文献索引:J. Nat. Prod. 61(6) , 709-12, (1998)

全文:HTML全文

摘要

(R)-(+)-nor-Roefractine (1) was synthesized by the Bischler-Napieralski route, using asymmetric reduction of the 1, 2-didehydro precursor imine with sodium (S)-N-CBZ-prolinyloxyborohydride. Compound 1 was able to displace [3H]-raclopride (a D2 dopamine receptor-selective ligand) from its specific binding sites in rat striatum with selectivity vs [3H]-SCH23390 (D1 dopamine receptor-selective ligand).

相关化合物

结构式 名称/CAS号 全部文献
4-甲氧基苯基乙酰氯 结构式 4-甲氧基苯基乙酰氯
CAS:4693-91-8