Journal of the American Chemical Society 2005-09-07

Small amounts of achiral beta-amino alcohols reverse the enantioselectivity of chiral catalysts in cooperative asymmetric autocatalysis.

François Lutz, Takashi Igarashi, Tsuneomi Kawasaki, Kenso Soai

文献索引：J. Am. Chem. Soc. 127 , 12206-12207, (2005)

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摘要

An asymmetric autocatalytic reaction has been catalyzed by a mixture of chiral and achiral beta-amino alcohols. The absolute configuration of the highly enantioenriched obtained product (>98% ee) was shown to depend not only on the absolute configuration of the chiral catalyst but also on the structure and the amount of achiral catalyst. Even in default versus the chiral catalyst, achiral catalysts were shown to be able to reverse the enantioselectivity of the reaction.