Organic & Biomolecular Chemistry 2003-04-07

The synthesis of trianglimines: on the scope and limitations of the [3 + 3] cyclocondensation reaction between (1R,2R)-diaminocyclohexane and aromatic dicarboxaldehydes.

Nikolai Kuhnert, Giulia M Rossignolo, Ana Lopez-Periago

文献索引：Org. Biomol. Chem. 1(7) , 1157-70, (2003)

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摘要

The synthesis of aromatic dicarboxaldehydes, using dilithiation methodology is described along with their reactivity, in the [3 + 3] cyclocondensation reaction, with (1R,2R)-diaminocyclohexane to give trianglimine macrocycles. The scope and limitations of the cyclocondensation reaction are studied and some comments on the properties of the novel macrocycles are made such as their conformation in solution and temperature dependent dynamic NMR behaviour.