Archiv der Pharmazie

Synthesis and Antiproliferative Activity of Some Androstene Oximes and Their O??Alkylated Derivatives

PC Acharya, R Bansal

文献索引：Acharya, Pratap Chandra; Bansal, Ranju Archiv der Pharmazie, 2014 , vol. 347, # 3 p. 193 - 199

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被引用次数: 4

摘要

In order to study the structure–activity relationship with respect to the cytotoxicity of steroidal oximes, several 6E-hydroximino-4-ene steroids and their O-alkylated derivatives were synthesized. The oxime ethers were solidified and purified by preparing their corresponding oxalate salts. The new derivatives as well as some previously synthesized ones were evaluated for in vitro antineoplastic activity against a panel of 60 cancer cell lines at 10 ...