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Organic Letters 2005-09-15

Expedient parallel synthesis of 2-amino-4-heteroarylpyrimidines.

Matthew G Bursavich, Sabrina Lombardi, Adam M Gilbert

文献索引:Org. Lett. 7(19) , 4113-6, (2005)

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摘要

[reaction: see text] An expedient synthesis of diverse 2-amino-4-heteroarylpyrimidines via a 2-chloropyrimidine intermediate is described. A series of potentially biologically active analogues have been synthesized in two parallel steps to afford focused arrays.

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