Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's …

Z Luo, L Liang, J Sheng, Y Pang, J Li, L Huang…

文献索引：Luo, Zonghua; Liang, Liang; Sheng, Jianfei; Pang, Yanqing; Li, Jianheng; Huang, Ling; Li, Xingshu Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 4 p. 1355 - 1361

全文：HTML全文

被引用次数: 24

摘要

Abstract A series of ebselen derivatives were designed, synthesised and evaluated as inhibitors of cholinesterases (ChEs) and glutathione peroxidase (GPx) mimics. Most of the compounds were found to be potent against AChEs and BuChE, compounds 5e and 5i, proved to be the most potent against AChE with IC 50 values of 0.76 and 0.46 μM, respectively. Among these hybrids, most of the compounds were found to be good GPx ...