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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Tetrahedron

A convergent total synthesis of mappicine ketone: A leading antiviral compound

JS Yadav, S Sarkar, S Chandrasekhar

文献索引：Yadav; Sarkar, Sanjita; Chandrasekhar Tetrahedron, 1999 , vol. 55, # 17 p. 5449 - 5456

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被引用次数: 26

摘要

An efficient total synthesis of the naturally occuring mappicine ketone 1 and mappicine 2 are described. The approach is based on the assembly of tricyclic amine 5 with pseudo acid chloride 20. A Friedlander condensation is utilized for the construction of the ABC skeleton and a periselective Diels-Alder approach is utilized for the preparation of the pseudo acid chloride.

4-氧代-吡略烷-1,3-二羧酸二乙酯结构式

4-氧代-吡略烷-1,3-二羧酸二乙酯

~%

ethyl 1,3-dihydropyrrolo[3,4-b]quinoline-2-carboxylate结构式

ethyl 1,3-dihyd...

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4-氧代-吡略烷-1,3-二羧酸二乙酯结构式

4-氧代-吡略烷-1,3-二羧酸二乙酯

~92%

1-乙氧羰基吡咯烷-3-酮结构式

1-乙氧羰基吡咯烷-3-酮

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ethyl 1,3-dihydropyrrolo[3,4-b]quinoline-2-carboxylate结构式

ethyl 1,3-dihyd...

~81%

2,3-Dihydro-1H-pyrrolo[3,4-b]quinoline结构式

2,3-Dihydro-1H-...

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2-((乙氧基羰基)氨基)乙酸甲酯结构式

2-((乙氧基羰基)氨基)乙酸甲酯

丙烯酸乙酯结构式

丙烯酸乙酯

~85%

4-氧代-吡略烷-1,3-二羧酸二乙酯结构式

4-氧代-吡略烷-1,3-二羧酸二乙酯

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未登录结构式

~%

mappicine ketone结构式

mappicine ketone

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1-ethyl-4-hydroxy-2-butynyl benzoate结构式

1-ethyl-4-hydro...

~%

mappicine ketone结构式

mappicine ketone

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5-ethoxy-4-formyl-3-(1-phenylcarbonyloxypropyl)furan结构式

5-ethoxy-4-form...

~%

mappicine ketone结构式

mappicine ketone

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2-chloro-4-chloromethyl-5-oxo-3-(1-phenylcarbonyloxypropyl)-2,5-dihydrofuran结构式

2-chloro-4-chlo...

~%

mappicine ketone结构式

mappicine ketone

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未登录结构式

~%

mappicine ketone结构式

mappicine ketone

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5-ethoxy-4-hydroxymethyl-3-(1-phenylcarbonyloxypropyl)furan结构式

5-ethoxy-4-hydr...

~%

mappicine ketone结构式

mappicine ketone

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3-chloromethyl-4-oxo-2-(1-phenylcarbonyloxypropyl)-4,6-dihydroindolizino[1,2-b]quinoline结构式

3-chloromethyl-...

~%

mappicine ketone结构式

mappicine ketone

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未登录结构式

~%

mappicine ketone结构式

mappicine ketone

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2-(4-phenylcarbonyloxy-2-hexynyloxy)tetrahydro-2H-pyran结构式

2-(4-phenylcarb...

~%

mappicine ketone结构式

mappicine ketone

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2,3-Dihydro-1H-pyrrolo[3,4-b]quinoline结构式

2,3-Dihydro-1H-...

~%

mappicine ketone结构式

mappicine ketone

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ethyl 1,3-dihydropyrrolo[3,4-b]quinoline-2-carboxylate结构式

ethyl 1,3-dihyd...

~%

mappicine ketone结构式

mappicine ketone

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3-methyl-4-oxo-2-(1-phenylcarbonyloxypropyl)-4,6-dihydroindolizino[1,2-b]quinoline结构式

3-methyl-4-oxo-...

~%

mappicine ketone结构式

mappicine ketone

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Facile syntheses of ABC ring skeleton of camptothecin and re...

[Chavan, Subhash P.; Pasupathy; Sivappa; Venkatraman Synthetic Communications, 2004 , vol. 34, # 17 p. 3099 - 3110]

Facile syntheses of ABC ring skeleton of camptothecin and re...

[Chavan, Subhash P.; Pasupathy; Sivappa; Venkatraman Synthetic Communications, 2004 , vol. 34, # 17 p. 3099 - 3110]

Facile syntheses of ABC ring skeleton of camptothecin and re...

[Chavan, Subhash P.; Pasupathy; Sivappa; Venkatraman Synthetic Communications, 2004 , vol. 34, # 17 p. 3099 - 3110]

Facile syntheses of ABC ring skeleton of camptothecin and re...

[Chavan, Subhash P.; Pasupathy; Sivappa; Venkatraman Synthetic Communications, 2004 , vol. 34, # 17 p. 3099 - 3110]