Organic & Biomolecular Chemistry 2009-03-21

Synthesis of glucose derivatives modified at the 4-OH as potential chain-terminators of cellulose biosynthesis; herbicidal activity of simple monosaccharide derivatives.

Emma van Dijkum, Ramona Danac, David J Hughes, Richard Wood, Anne Rees, Brendan L Wilkinson, Antony J Fairbanks

文献索引：Org. Biomol. Chem. 7(6) , 1097-105, (2009)

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摘要

A series of D-glucose derivatives that have been modified at C-4 were synthesised from D-galactose as potential chain terminators of cellulose biosynthesis. Two compounds displayed herbicidal activity in pre-emergence tests and in addition a cell expansion assay at higher concentrations revealed symptomology of a third compound that was indicative of inhibition of cellulose biosynthesis.