The Journal of Organic Chemistry

Mild conversion of carboxamides and carboxylic acid hydrazides to acids and esters

WJ Greenlee, ED Thorsett

文献索引：Greenlee, William J.; Thorsett, Eugene D. Journal of Organic Chemistry, 1981 , vol. 46, p. 5351 - 5353

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被引用次数: 46

摘要

Although unsubstituted carboxamides are readily prepared from the corresponding methyl or ethyl esters, the conversion of carboxamides to esters is often difficult. The existing methods for this transformation, or that to the carboxylic acid, usually call for treatment with strong acid or base under conditions generally incompatible with sensitive substrates.'S2 Although amide hydrolysis via nitrosation has been carried out under neutral conditions, 4 ...