Hypolipidemic activity of phthalimide derivatives V: reduced and hydrolytic products of simple cyclic imides

JM Chapman, SD Wyrick, PJ Voorstad…

文献索引：Chapman Jr.; Wyrick; Josee Voorstad; et al. Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 10 p. 1482 - 1484

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被引用次数: 41

摘要

Abstract A series of cyclic imides and related compounds have previously been shown to possess hypolipidemic activity at the low dose level of 20 mg/kg/d. Hydrolytic and reduced products of the cyclic imides were synthesized and examined to discern if possible metabolic products were the active chemical species of these hypolipidemic agents. Phthalimide proved to be the most active cyclic imide tested. Unfortunately, the new ...