Rapid and Efficient Access to Secondary Arylmethylamines

…, J Raushel, DL Sandrock, SD Dreher…

文献索引：Fleury-Bregeot, Nicolas; Raushel, Jessica; Sandrock, Deidre L.; Dreher, Spencer D.; Molander, Gary A. Chemistry - A European Journal, 2012 , vol. 18, # 31 p. 9564 - 9570

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被引用次数: 17

摘要

Abstract Ammoniomethyl trifluoroborates are very powerful reagents that can be used to access biologically relevant aryl-and heteroaryl-methylamine motifs via Suzuki–Miyaura cross-couplings. Until now, this method was limited to the production of tertiary and primary amines. The synthesis of a large array of secondary ammoniomethyltrifluoroborates has been achieved through a one step nucleophilic substitution reaction on the potassium ...