H-D-Tic-OH
更新时间：2024-09-17 06:09:40
| 常用名 | (R)-(+)-1,2,3,4-四氢异喹啉-3-羧酸 | CAS号 | 103733-65-9 |
|---|---|---|---|
| 价格 | ￥需询单/1kg ￥需询单/1g | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： (R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid is a constrained Phe analogue which can fold into a beta-bend and a helical structure, and to adopt a preferred side-chain disposition in the peptide.IC50 value:Target: Three Tic-containing (Tic = 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) model peptides were synthesized to assess the tendency of this constrained Phe analogue to fold into a beta-bend and a helical structure, and to adopt a preferred side-chain disposition. The results of the solution conformational analysis, performed by using Fourier transform infrared absorption and 1H nuclear magnetic resonance, indicate that in chloroform the -Aib-D-Tic-Aib-, -(Aib)2-D-Tic-(Aib)2-, and -L-Pro-D-Tic- sequences fold into intramolecularly H-bonded forms to a great extent. An X-ray diffraction analysis on p-BrBz-(Aib)2-DL-Tic-(Aib)2-OMe monohydrate and p-BrBz-L-Pro-D-Tic-NHMe allows us to conclude that, while the pentapeptide methylester forms an incipient (distorted) 3(10)-helix, the dipeptide methylamide adopts a type-II beta-bend conformation. In both cases, the D-Tic side-chain conformation is D, gauche(-). The implications for the use of the Tic residue in designing conformationally restricted analogues of bioactive peptides are briefly discussed. 物理化学性质： CAS号：103733-65-9 常用中文名：(R)-(+)-1,2,3,4-四氢异喹啉-3-羧酸 常用英文名：D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid 分子式：C10H11NO2 分子量：177.200 密度：1.2±0.1 g/cm3 沸点：372.0±42.0 °C at 760 mmHg 熔点：N/A 闪点：178.8±27.9 °C 储存条件：2-8°C |
- 南京肽业生物科技有限公司
- 江苏省 南京市 六合区
- 产品名：H-D-Tic-OH
- 价格： ￥需询单/10g ￥需询单/100g ￥需询单/1kg ￥需询单/10kg
- 纯度：98.0%
- 备货期：7天
- 联系人：滕经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：(R)-1,2,3,4-四氢-3-异喹啉羧酸
- 价格： ￥31.9/250mg ￥29.9/50mg ￥30.9/100mg ￥92.9/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$198/10mM*1mLinDMSO