Tideglusib
更新时间：2025-08-27 11:53:37
| 常用名 | 4-苄基-2-(萘-1-基)-[1,2,4]噻二唑烷-3,5-二酮 | CAS号 | 865854-05-3 |
|---|---|---|---|
| 价格 | ￥879.0/10ml ￥772.0/5mg ￥1302.0/10mg ￥2474.0/100mg | 纯度 | 98.0% |
| 备货期 | 3天 | 库存 | 现货 |
| 产品网页 | http://www.szhbsj.com.cn/Prt-HBA01-14872.asp | ||
| 产品详情（用途，包装等）
生物活性 Tideglusib(NP-031112)是不可逆的非ATP竞争性GSK-3β抑制剂，IC50为60 nM。 Tideglusib(NP-031112) is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM. IC50 value: 60 nM [1] Target: GSK-3β in vitro: Tideglusib irreversibly inhibits GSK-3, reduces tau phosphorylation, and prevents apoptotic death in human neuroblastoma cells and murineprimary neurons [1]. Tideglusib (2.5 μM) inhibits glutamate-induced glial activation as evidenced by decreased TNF-α and COX-2 expression in rat primary astrocyte or microglial cultures. Tideglusib (2.5 μM) also exerts a potent neuroprotective effect on cortical neurons from glutamate-induced excitotoxicity as evidenced by significant reduction in the number of Annexin-V-positive cells in rat primary astrocyte or microglial cultures [2]. in vivo: Tideglusib (50 mg/kg) injected into the adult male Wistar rats hippocampus dramatically reduces kainic acid-induced inflammation and has a neuroprotective effect in the damaged areas of the hippocampus [2]. Tideglusib (200 mg/kg, oral) results in lower levels of tau phosphorylation, decreased amyloid deposition and plaque-associated astrocytic proliferation, protection of neurons in the entorhinal cortex and CA1 hippocampal subfield against cell death, and prevention of memory deficits in APP/tau double transgenic mice [3]. |
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：Tideglusib(NP-031112)
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿摩尔生物科技有限公司
- 上海市 上海市 奉贤区
- 产品名：4-苄基-2-(萘-1-基)-1,2,4-噻二唑啉-3,5-二酮
- 价格： ￥需询单/100mg ￥需询单/10mg ￥需询单/1g ￥需询单/250mg
- 纯度：98.0%
- 备货期：需询单
- 联系人：王汐瑶
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：Tideglusib
- 价格： ￥249.9/25mg ￥69.9/5mg ￥699.9/100mg ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
- 武汉敬康恩生物医药科技有限公司
- 湖北省 武汉市 东西湖区
- 产品名：Tideglusib
- 价格：
- 纯度：98.0%
- 备货期：需询单
- 联系人：周经理
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4-苄基-2-(萘-1-基)-[1,2,4]噻二唑烷-3,5-二酮生产厂家
参考价格：$110/10mM*1mLinDMSO