| 常用名 | 杀结核菌素 | CAS号 | 69-33-0 |
|---|---|---|---|
| 价格 | $需询单/1g | 纯度 | 95.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情(用途,包装等)
用途: Tubercidin (7-Deazaadenosine) is an adenosine analog, is an antibiotic obtained from Streptomyces tubercidicus.Target: AntibacterialTubercidin inhibits the growth of Streptococcus faecalis by 50 % at a concentration of 20 nM. Tubercidin is not subject to cleavage by adenosine phosphorylase or to deamination by adenosine deaminase. The antibiotic served as a substrate for numerous enzymes involved in the anabolism of adenosine, as demonstrated by its incorporation into RNA and DNA, and by the formation of nicotinamide-deaza-adenine dinucleotide. Tubercidin proves to be a weak inhibitor of adenosine phosphorylase, and interfered with the phosphorylation of adenosine and AMP. The inhibition of the growth of S. faecalis by Tubercidin is prevented by purine and pyrimidine nucleosides, ribose 5-phosphate, pyruvate, and certain amino acids. In the presence of Tubercidin, growing cultures of the test organism used pyruvate instead of glucose, whereas in the absence of the antibiotic glucose served as the main source of energy. It is suggested, therefore, that the impairment of growth is due primarily to the interference of Tubercidin with the utilization of glucose. 物理化学性质: CAS号:69-33-0 常用中文名:杀结核菌素 常用英文名:7-Deazaadenosine(Tubercidin) 分子式:C11H14N4O4 分子量:266.253 密度:1.9±0.1 g/cm3 沸点:648.8±55.0 °C at 760 mmHg 熔点:247-248 °C (decomp) 闪点:346.2±31.5 °C 储存条件:室温 |