5-Fluoro-2'-Deoxyuridine
更新时间：2021-02-15 19:15:06
| 常用名 | 5-氟-2'-脱氧脲核苷 | CAS号 | 50-91-9 |
|---|---|---|---|
| 价格 | $需询单/1g | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Floxuridine (5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites with an GI50 of 5.1 μM for the inhibition of PEPT1. IC50 value: Target: Nucleoside antimetabolite/analogFloxuridine (Fludara) is a prodrug of floxuridine and an oncology agent with an GI50 of 5.1 μM for the inhibition of MDCK/PEPT1. Floxuridine (Fludara) belongs to the class known as antimetabolites. Floxuridine (Fludara) is most often used in the treatment of colorectal cancer. Floxuridine, an analog of 5-fluorouracil, is a fluorinated pyrimidine. Floxuridine (Fludara) works because it is broken down by the body into its active form, which is the same as a metabolite of 5-Fluorouracil [1]. FdUrd induced an immediate increase in tumor uptake of 5-[(125)I]iodo-2'-deoxyuridine, that vanished after 6 h, as also confirmed by flow cytometry. Biodistribution measurements showed that FdUrd pretreatment increased [(18)F]FLT uptake in all tumors by factors of 3.2 to 7.8 compared with controls, while [(18)F]FDG tumor uptake was about fourfold and sixfold lower in breast cancers and lymphoma. Dynamic PET in FdUrd pretreated mice showed that [(18)F]FLT uptake in all tumors increased steadily up to 1.5 h. MRI showed a well-vascularized homogenous lymphoma with high [(18)F]FLT uptake, while in breast cancer, a central necrosis shown by MRI was inactive in PET, consistent with the histomorphological analysis [2].Clinical indications: Colorectal tumor; Liver tumorFDA Approved Date: December 1970 物理化学性质： CAS号：50-91-9 常用中文名：5-氟-2'-脱氧脲核苷 常用英文名：Floxuridine 分子式：C9H11FN2O5 分子量：246.192 密度：1.8±0.1 g/cm3 沸点：483.0±55.0 °C at 760 mmHg 熔点：148 °C(lit.) 闪点：245.9±31.5 °C 储存条件：2~8°C |
- 上海化源生化科技有限公司
- 上海市 上海市 普陀区
- 产品名：5-氟-2'-脱氧尿苷
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：化源网
- 云南西力生物技术股份有限公司
- 云南省 昆明市 盘龙区
- 产品名：2'-脱氧-5-氟尿苷
- 价格： ￥需询单/5mg
- 纯度：98.0%
- 备货期：10天
- 联系人：郑雪平
- 上海吉至生化科技有限公司
- 上海市 上海市 奉贤区
- 产品名：5-氟-2'-脱氧尿苷
- 价格： ￥1168.0/25g ￥348.0/5g ￥108.0/1g
- 纯度：98.0%
- 备货期：2天
- 联系人：刘佳
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：FdUrD
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海脉铂医药科技有限公司
- 上海市 上海市 嘉定区
- 产品名：Floxuridine
- 价格： ￥359.0/25mg ￥929.0/100mg ￥589.0/1g ￥需询单/1g
- 纯度：98.0%
- 备货期：2天
- 联系人：李先生
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：5-氟-2'-脱氧尿苷
- 价格： ￥129.9/1g ￥59.9/250mg ￥1999.9/25g ￥499.9/5g
- 纯度：99.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：￥152.9/1g