| 常用名 | 泛昔洛韦 | CAS号 | 104227-87-4 |
|---|---|---|---|
| 价格 | ¥需询单/1kg ¥需询单/100g ¥需询单/100kg ¥需询单/1ton | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情(用途,包装等)
用途: Famciclovir(BRL 42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections.IC50 Value: Refer to penciclovirTarget: HSVFamciclovir is the diacetyl 6-deoxy analog of the active antiviral compound penciclovir with potential use in the treatment of infections caused by the herpes family of viruses [1]. Famciclovir, a synthetic acyclic guanine derivative, is a prodrug which, after oral administration, is rapidly metabolised to the highly bioavailable antiviral compound penciclovir [2].in vitro: Famciclovir induced rapid, dose-dependent suppression of viral replication and reduction in alanine aminotransferase (ALT), with greatest efficacy in the 500-mg tid treatment group. HBV DNA reduction was maintained throughout the treatment period. ALT also steadily declined during the treatment period [3]. in vivo: In rat, following dosing at 40 mg/kg, famciclovir was rapidly and extensively metabolized to the active antiviral compound penciclovir, which reached peak concentrations in the plasma (mean 3.5 micrograms/ml) at 0.5 h [4]. Necrotic hepatitis was significantly (p 物理化学性质: CAS号:104227-87-4 常用中文名:泛昔洛韦 常用英文名:Famciclovir 分子式:C14H19N5O4 分子量:321.332 密度:1.4±0.1 g/cm3 沸点:550.2±60.0 °C at 760 mmHg 熔点:102-104°C 闪点:286.6±32.9 °C 储存条件:-20°C Freezer |