木香烃内酯
更新时间：2024-10-04 09:14:07
| 常用名 | 木香烃内酯 | CAS号 | 553-21-9 |
|---|---|---|---|
| 价格 | ￥280.0/20mg | 纯度 | 98.0% |
| 备货期 | 1天 | 库存 | 900 mg |
| 产品详情（用途，包装等）
用途： Costunolide, a sesquiterpene lactone, exhibits anti-inflammatory and anti-oxidant properties and mediates apoptosis.IC50 Value: 6.2 - 9.8 ug/mL(sarcoma cells viability)[3]Target: Apoptosis inducerin vitro: Costunolide significantly inhibited RANKL-induced BMM differentiation into osteoclasts in a dose-dependent manner without affecting cytotoxicity. Costunolide did not regulate the early signaling pathways of RANKL, including the mitogen-activated protein kinase and NF-κB pathways. However, costunolide suppressed nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) expression via inhibition of c-Fos transcriptional activity without affecting RANKL-induced c-Fos expression. The inhibitory effects ofcostunolide were rescued by overexpression of constitutively active (CA)-NFATc1 [1]. Exposure of T24 cells to costunolide was also associated with increased expression of Bax, down-regulation of Bcl-2, survivin and significant activation of caspase-3, and its downstream target PARP [2]. Both costunolide and dehydrocostus lactone inhibited cell viability dose- and time-dependently. IC50 values ranged from 6.2 ug/mL to 9.8 ug/mL. Cells treated with costunolide showed no changes in cell cycle, little in caspase 3/7 activity, and low levels of cleaved caspase-3 after 24 and 48 h [3].in vivo: Neither costunolide nor alpha-MGBL affected the blood-ethanol elevation in pylorus-ligated rats or that induced by intraperitoneal and intraduodenal ethanol administration [4]. Costunolide and alpha-MGBL suppressed gastric emptying in rats given 20% ethanol and 1% sodium carboxymethyl cellulose.Clinical trial: 物理化学性质： CAS号：553-21-9 常用中文名：木香烃内酯 常用英文名：Costunolide 分子式：C15H20O2 分子量：232.318 密度：1.0±0.1 g/cm3 沸点：385.4±42.0 °C at 760 mmHg 熔点：106 °C 闪点：162.0±25.3 °C 储存条件：Store at -20°C |
- 上海化源生化科技有限公司
- 上海市 上海市 普陀区
- 产品名：木香烃内酯
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：化源网
- 上海吉至生化科技有限公司
- 上海市 上海市 奉贤区
- 产品名：木香烃内酯
- 价格： ￥278.0/20mg
- 纯度：98.0%
- 备货期：2天
- 联系人：刘佳
- 上海脉铂医药科技有限公司
- 上海市 上海市 嘉定区
- 产品名：Costunolide
- 价格： ￥829.0/10mg ￥489.0/1g ￥549.0/5mg ￥需询单/1g
- 纯度：98.0%
- 备货期：2天
- 联系人：李先生
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：木香烃内酯
- 价格： ￥637.9/25mg ￥308.9/5mg ￥570.9/20mg ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
- 盼得（上海）国际贸易有限公司
- 上海市 上海市 徐汇区
- 产品名：木香烃内酯
- 价格： ￥需询单/500g ￥需询单/1kg ￥需询单/25kg ￥需询单/200kg
- 纯度：0.0%
- 备货期：需询单
- 联系人：叶经理
- 武汉吉鑫益邦生物科技有限公司
- 湖北省 武汉市 东西湖区
- 产品名：木香烃内酯
- 价格： ￥需询单/500g ￥需询单/1kg ￥需询单/25kg ￥需询单/200kg
- 纯度：0.0%
- 备货期：需询单
- 联系人：周美玲
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参考价格：$79/10mM*1mLinDMSO