淫羊藿素
更新时间：2023-01-17 17:48:24
| 常用名 | 去水淫羊藿黄素； 脱水淫羊藿素 | CAS号 | 118525-40-9 |
|---|---|---|---|
| 价格 | ￥需询单/20mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Icaritin(Anhydroicaritin) is a component of Epimedium flavonoid isolated from Herba Epimedii; enhances osteoblastic differentiation of mesenchymal stem cells (MSCs) while it inhibits adipogenic differentiation of MSCs by inhibiting PPAR-g pathway.IC50 value:Target: in vitro: Icaritin was unable to promote proliferation, migration and tube like structure formation by human umbilical vein endothelial cells (HUVECs) in vitro [1]. Icaritin potently inhibited proliferation of K562 cells (IC50 was 8 μM) and primary CML cells (IC50 was 13.4 μM for CML-CP and 18 μM for CML-BC), induced CML cells apoptosis and promoted the erythroid differentiation of K562 cells with time-dependent manner. Furthermore, Icaritin was able to suppress the growth of primary CD34+ leukemia cells (CML) and Imatinib-resistant cells, and to induce apoptosis [2]. icaritin strongly inhibited the growth of breast cancer MDA-MB-453 and MCF7 cells. At concentrations of 2-3 μM, icaritin induced cell cycle arrest at the G(2)/M phase accompanied by a down-regulation of the expression levels of the G(2)/M regulatory proteins such as cyclinB, cdc2 and cdc25C. Icaritin at concentrations of 4-5 μM, however, induced apoptotic cell death characterized by the accumulation of the annexin V- and propidium iodide-positive cells, cleavage of poly ADP-ribose polymerase (PARP) and down-regulation of the Bcl-2 expression [3].in vivo: In mouse leukemia model, Icaritin could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells as effective as Imatinib without suppression of bone marrow. Icaritin could up-regulate phospho-JNK or phospho-C-Jun and down-regulate phospho-ERK, phospho-P-38, Jak-2, phospho-Stat3 and phospho-Akt expression with dose- or time-dependent manner [2]. 物理化学性质： CAS号：118525-40-9 常用中文名：去水淫羊藿黄素； 脱水淫羊藿素 常用英文名：Icaritin 分子式：C21H20O6 分子量：368.380 密度：1.4±0.1 g/cm3 沸点：582.0±50.0 °C at 760 mmHg 熔点：239ºC 闪点：206.7±23.6 °C 储存条件：2-8°C |
- 云南西力生物技术股份有限公司
- 云南省 昆明市 盘龙区
- 产品名：淫羊藿素
- 价格： ￥需询单/5mg
- 纯度：98.0%
- 备货期：10天
- 联系人：郑雪平
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：淫羊藿素
- 价格： ￥49.9/10mg ￥89.9/25mg ￥144.9/50mg ￥514.9/1ml
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
- 四川恒诚致远生物科技有限公司
- 四川省 成都市 温江区
- 产品名：淫羊藿素
- 价格： ￥需询单/5mg ￥需询单/20mg ￥需询单/100mg ￥需询单/1g
- 纯度：98.0%
- 备货期：需询单
- 联系人：张半夏
- 上海阿摩尔生物科技有限公司
- 上海市 上海市 奉贤区
- 产品名：3,5,7-三羟基-2-(4-甲氧基苯基)-8-(3-甲基丁-2-烯-1-基)-4H-苯并吡喃-4-酮
- 价格： ￥需询单/100mg ￥需询单/10mg ￥需询单/1g ￥需询单/1mg
- 纯度：98.0%
- 备货期：需询单
- 联系人：王汐瑶
- 武汉敬康恩生物医药科技有限公司
- 湖北省 武汉市 东西湖区
- 产品名：Icaritin
- 价格： ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：周经理
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参考价格：$79/10mM*1mLinDMSO