奥卡西平
更新时间：2024-01-29 13:38:58
| 常用名 | 奥卡西平 | CAS号 | 28721-07-5 |
|---|---|---|---|
| 价格 | ￥需询单/1200kg | 纯度 | 98.0% |
| 备货期 | 7天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Oxcarbazepine inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.Target: Sodium ChannelOxcarbazepine is an antiepileptic drug with a chemical structure similar to carbamazepine, but with different metabolism. Oxcarbazepine is rapidly reduced to 10,11-dihydro-10-hydroxy-carbazepine (monohydroxy derivative, MHD), the clinically relevant metabolite of oxcarbazepine. MHD has (S)-(+)- and the (R)-(-)-enantiomer [1]. Oxcarbazepine (oxcarb) 600 and 900 mg (2360 and 3540 mumol) was taken by 3 volunteers (2 female, 1 male; 45-67 kg; age 22-34 years) after an overnight fast. Blood, saliva and urine were collected for the next 72 h for assay of oxcarb, 10,11-dihydro-10-hydroxy-carbamazepine (OHcarb), and 10,11-dihydro-trans-10,11-dihydroxy-carbamazepine (diol). Oxcarb reached a maximum level of about 1 microgram/ml (3.93 mumol/l) within 1 h and dropped below the detection limit (0.1 microgram/ml = 0.39 mumol/l) within 3 h. The active metabolite OHcarb appeared in the blood before oxcarb and reached the higher maximum level of 7.4 microgram/ml (29 mumol/l) after 7 h [2]. Clinical indications: EpilepsyToxicity: Isolated cases of overdose with oxcarbazepine have been reported. The maximum dose taken was approximately 24,000 mg. All patients recovered with symptomatic treatment. 物理化学性质： CAS号：28721-07-5 常用中文名：奥卡西平 常用英文名：Oxcarbazepine 分子式：C15H12N2O2 分子量：252.268 密度：1.3±0.1 g/cm3 沸点：457.2±55.0 °C at 760 mmHg 熔点：215-216°C 闪点：230.3±31.5 °C 储存条件：Store at RT |
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：奥卡西平
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
查看所有供应商和价格请点击：
参考价格：$79/10mM*1mLinDMSO