N-6-异喹啉基-N-[2-氧代-2-(1-吡咯烷基)乙基]脲
更新时间：2025-08-02 13:44:10
| 常用名 | SGC707 | CAS号 | 1687736-54-4 |
|---|---|---|---|
| 价格 | ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 3天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： SGC707 is a first-in-class PRMT3 chemical probe which is a potent, selective, and cell-active allosteric inhibitor of PRMT3 with IC50 of 31 nM.IC50 value: 31 nMTarget: PRMT3in vitro: SGC707 is the first PRMT3 chemical probe. SGC707 is a potent PRMT3 inhibitor (IC50=31±2 nM, KD=53±2 nM) with outstanding selectivity (selective against 31 other methyltransferases and more than 250 non-epigenetic targets). SGC707 can engage PRMT3 and effectively inhibit its catalytic activity in cells and that overexpressed PRMT3 can methylate histone H4 in cells. SGC707 stabilizes PRMT3 in both HEK293 and A549 cells with EC50 values of 1.3 μM and 1.6 μM in PRMT3 InCELL Hunter Assays.in vivo: SGC707 is bioavailable and suitable for animal studies. This well characterized chemical probe is an excellent tool to further study the role of PRMT3 in health and disease. We assessed in vivo pharmacokinetic (PK) properties of SGC707. Intraperitoneal injection of SGC707 at 30 mg/kg gave good plasma exposure in CD-1 male mice over 6 h with the peak plasma level of 38000 nM. The plasma level of SGC707 at 6 h post injection was 208 nM, more than 2-fold higher than its IC50 value in the cellular assay and the half-life of SGC707 was about 1 h. This mdose was well tolerated by the test animals. These results suggest that SGC707 is suitable for animal studies in addition to cell-based studies. 物理化学性质： CAS号：1687736-54-4 常用中文名：SGC707 常用英文名：SGC707 分子式：C16H18N4O2 分子量：298.340 密度：1.3±0.1 g/cm3 沸点：538.5±46.0 °C at 760 mmHg 熔点：N/A 闪点：279.5±29.0 °C 储存条件：-20℃ |
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：SGC707
- 价格： ￥679.9/1ml ￥1104.9/100mg ￥350.9/25mg ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
2881459338
复制
- 上海吉至生化科技有限公司
- 上海市 上海市 奉贤区
- 产品名：1-(异喹啉-6-基)-3-(2-氧代-2-(吡咯烷-1-基)乙基)脲
- 价格： ￥586.0/5mg ￥5846.0/100mg ￥1796.0/25mg ￥3406.0/50mg
- 纯度：98.0%
- 备货期：2天
- 联系人：刘佳
3007522982
复制
- 长沙福臻生物科技有限公司
- 湖南省 长沙市 芙蓉区
- 产品名：N-6-异喹啉基-N'-[2-氧代-2-(1-吡咯烷基)乙基]脲
- 价格： ￥需询单/100mg ￥需询单/500mg ￥需询单/1g ￥需询单/5g
- 纯度：98.0%
- 备货期：需询单
- 联系人：张经理
3756953817
复制
18229892877
复制
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：SGC707
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
351666998
复制
13311869306
复制
查看所有供应商和价格请点击：
参考价格：$79/10mM*1mLinDMSO