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Aminophylline

更新时间:2022-02-25 18:03:53 采购访问:37次

常用名 氨茶碱 CAS号 317-34-0
价格 $需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg 纯度 98.0%
备货期 需询单 库存 询单
 产品详情(用途,包装等)
用途:
Aminophylline is a competitive nonselective phosphodiesterase inhibitor that is used to treat airway obstruction from asthma or COPD.Target: PhosphodiesteraseAminophylline is a compound of the bronchodilator theophylline with ethylenediamine in 2:1 ratio. The ethylenediamine improves solubility, and the aminophylline is usually found as a dihydrate. Aminophylline is less potent and shorter-acting than theophylline. Its most common use is in the treatment of airway obstruction from asthma or COPD. It is used off-label as a reversal agent during nuclear stress testing. Aminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor.Adenosine is an endogenous extracellular messenger that can regulate myocardial oxygen needs. It acts through cellular surface receptors which effect intracellular signalling pathways to increase coronary artery blood flow, slow heart rate, block atrioventricular node conduction, suppress cardiac automaticity, and decrease β-adrenergic effects on contractility. Adenosine also antagonizes chronotropic and ionotropic effects of circulating catecholamines. Overall, adenosine decreases the heart's rate and force of contraction, which increases blood supply to the cardiac muscle. Given specific circumstances this mechanism (which is intended to protect the heart) may cause atropine-resistant refractory bradyasystole. Adenosine's effects are concentration-dependent. Adenosine's receptors are competitively antagonized by methylxanthines such as aminophylline. Aminophylline competitively antagonizes the cardiac actions of adenosine at the cell surface receptors. Thus, it increases heart rate and contractility.
物理化学性质:
CAS号:317-34-0
常用中文名:氨茶碱
常用英文名:Aminophylline
分子式:C16H24N10O4
分子量:420.426
密度:N/A
沸点:454.1ºC at 760mmHg
熔点:269-270 °C
闪点:N/A
储存条件:−20°C

供应商信息

达阳化工(杭州)有限公司 认证供应商

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地区: 浙江省 杭州市 西湖区
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联系人电话:+86-571-8893-8639
邮件:enquiry@dycnchem.com
网址:http://www.dycnchem.com
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年贸易额:10 to 20 million USD
外贸占销售比例:90%
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参考价格:$66/10mM*1mLinDMSO
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