Gabexate mesylate
更新时间：2023-02-15 09:11:50
采购访问：32次
| 常用名 | 甲磺酸加贝酯 | CAS号 | 56974-61-9 |
|---|---|---|---|
| 价格 | $需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Gabexate Mesylate is a Factor X inhibitor; serine protease inhibitor .Target: Factor XGabexate mesylate is a non-antigenic synthetic inhibitor of trypsin-like serine proteinases that is therapeutically used in the treatment of pancreatitis and disseminated intravascular coagulation and as a regional anticoagulant for hemodialysis. Values of the inhibition constant (K(i)) for gabexate mesylate binding to human and bovine tryptase were 3.4 x 10(-9) M and 1.8 x 10(-7) M (at pH 7.4 and 37.0 degrees ), respectively. Gabexate mesylate inhibited the fibrinogenolytic activity of human tryptase [1]. Gabexate Mesylate decreased the TNFalpha production of LPS-stimulated monocytes as shown by the inhibition of mRNA expression and increased the IL-10 production of LPS-stimulated monocytes. Gabexate Mesylate also suppressed the NFkappaB activity of LPS-stimulated monocytes. Inhibitory effect of Gabexate Mesylate on the TNFalpha production of activated human monocytes is mediated by the suppression of NFkappaB activation [2]. Gabexate mesylate inhibits competitively constitutive and inducible NO synthase (cNOS and iNOS, respectively), with Kivalues of 1.0×10?4M and 5.0×10?3M, respectively, at pH 7.4 and 37.0°C. gabexate mesylate increases iNOS mRNA expression in rat C6 glioma cells, as induced byE. colilipopolysaccharide plus interferon-γ. Gabexate mesylate inhibits dose-dependently nitrite production (i.e. NO release) in rat C6 glioma cells, as induced byE. colilipopolysaccharide plus interferon-γ [3]. 物理化学性质： CAS号：56974-61-9 常用中文名：甲磺酸加贝酯 常用英文名：Gabexate mesylate 分子式：C17H27N3O7S 分子量：417.477 密度：N/A 沸点：508.6ºC at 760 mmHg 熔点：91 °C 闪点：261.4ºC 储存条件：-20°C |
达阳化工（杭州）有限公司
认证状态：已认证供应商
商品数：50181件
电话：+86571-88938639
地址：浙江省杭州市西湖区文三路259号2栋9楼
地区： 浙江省 杭州市 西湖区
联系人：王小姐
联系人电话：+86-571-8893-8639
邮件：enquiry@dycnchem.com
网址：http://www.dycnchem.com
主要市场：Mainly in Southeast Asia and European and American markets
年贸易额：10 to 20 million USD
外贸占销售比例：90%
主要合作伙伴：
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：甲磺酸加贝酯
- 价格：
- 纯度：99.0%
- 备货期：10天
- 联系人：徐经理
- 江西瑞威尔生物科技有限公司
- 江西省 吉安市 峡江县
- 产品名：甲磺酸加贝酯
- 价格： ￥需询单/10mg ￥需询单/100mg ￥需询单/10g ￥需询单/100g
- 纯度：98.0%
- 备货期：1天
- 联系人：李经理
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参考价格：$112/10mM*1mLinWater