2',3'-DIDEOXY-3'-FLUORO-GUANOSINE
更新时间：2021-07-26 18:31:52
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| 常用名 | 2',3'-二脱氧-3'-氟鸟苷 | CAS号 | 92562-88-4 |
|---|---|---|---|
| 价格 | $需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Lagociclovir(MIV-210) is a prodrug of 3'-fluoro-2',3'-dideoxyguanosine with high oral bioavailability in humans and potent activity against HBV. IC50 value:Target: Anti-HBV compoundOral administration of MIV-210 at 20 or 60 mg/kg of body weight/day induced a rapid virological response in chronically infected woodchucks, reducing serum WHV DNA levels by 4.75 log10 and 5.72 log10, respectively, in 2 weeks. Further, a daily dose of 10 mg/kg decreased the serum WHV load 400-fold after 4 weeks of treatment, and a dose of 5 mg/kg/day was sufficient to maintain this antiviral effect during the following 6-week period. MIV-210 at 20 or 60 mg/kg/day reduced the liver WHV DNA load 200- to 2,500-fold from pretreatment levels and, importantly, led to a 2.0 log10 drop in the hepatic content of WHV covalently closed circular DNA. 物理化学性质： CAS号：92562-88-4 常用中文名：2',3'-二脱氧-3'-氟鸟苷 常用英文名：Lagociclovir 分子式：C10H12FN5O3 分子量：269.232 密度：2.0±0.1 g/cm3 沸点：633.5±65.0 °C at 760 mmHg 熔点：N/A 闪点：336.9±34.3 °C |
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