Desloratadine
更新时间：2022-02-12 21:16:51
采购访问：37次
| 常用名 | 地氯雷他定 | CAS号 | 100643-71-8 |
|---|---|---|---|
| 价格 | $需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Desloratadine(Sch34117) is a potent antagonist for human histamine H1 receptor used to treat allergies.Target: Histamine H1 ReceptorDesloratadine binds to the human H1 receptor with Ki value of 0.87 nM in displacing tritiated mepyramine. Desloratadine (100 nM to 10 μM) inhibits both IgE-mediated and non-IgE-mediated generation of the cytokines IL-4 and IL-13 by human basophils. Desloratadine (300 nM to 100 μM) inhibits both IgE and non-IgE-mediated histamine release from human peripheral blood basophils. Desloratadine (0.1 μM to 10 μM) is also shown to inhibit platelet-activating factor-induced eosinophil chemotaxis and TNF-α-induced eosinophil adhesion in eosinophils obtained from patients with allergic rhinitis or allergic asthma [1]. Desloratadine (1 μM-10 μM) dose-dependently inhibits the release of histamine and LTC4 from human basophils. Desloratadine (0.1 μM-10 μM) dose-dependently inhibits IL-13 secretion from basophils activated with IL-3 and PMA from human basophils. Desloratadine (10 μM) pretreatment results in a substantial decrease of the induced cytokine message in cultured basophils. Desloratadine (10 μM) pretreatment causes approximately an 80% reduction in the IL-4 message accumulated with anti-IgE activation in cultured basophils. Desloratadine (10 μM) also inhibits the histamine and IL-4 protein secreted into the supernatants of cultured basophils [2]. [3H]Desloratadine binds to the human histamine H1 receptor expressed in CHO cells with Kd of 1.1 nM. Desloratadine is 52, 57, 194, and 153 times more potent than cetirizine, ebastine, fexofenadine, and loratadine, respectively, in competition-binding studies [3]. 物理化学性质： CAS号：100643-71-8 常用中文名：地氯雷他定 常用英文名：Desloratadine 分子式：C19H19ClN2 分子量：310.821 密度：1.2±0.1 g/cm3 沸点：467.9±45.0 °C at 760 mmHg 熔点：150-151°C 闪点：236.8±28.7 °C 储存条件：2-8°C |
达阳化工（杭州）有限公司
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主要市场：Mainly in Southeast Asia and European and American markets
年贸易额：10 to 20 million USD
外贸占销售比例：90%
主要合作伙伴：
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：地氯雷他定
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
- 广东翁江化学试剂有限公司
- 广东省 韶关市 翁源县
- 产品名：地氯雷他定
- 价格： ￥100.0/1g
- 纯度：98.0%
- 备货期：需询单
- 联系人：朱丽丹
- 盼得（上海）国际贸易有限公司
- 上海市 上海市 徐汇区
- 产品名：地氯雷他定
- 价格： ￥需询单/500g ￥需询单/1kg ￥需询单/25kg ￥需询单/200kg
- 纯度：0.0%
- 备货期：需询单
- 联系人：叶经理
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参考价格：￥78/1g