| 常用名 | 米诺地尔 | CAS号 | 38304-91-5 |
|---|---|---|---|
| 价格 | ¥1200.0/1kg ¥5000.0/5kg | 纯度 | 98.0% |
| 备货期 | 2天 | 库存 | 现货 |
| 产品详情(用途,包装等)
用途: Minoxidil(U 10858) is an antihypertensive vasodilator medication. Target: potassium channel Minoxidil, a potent antihypertensive agent, induces generalized hypertrichosis when administered systemically, or localized hair regrowth when applied topically to sites of severe alopecia areata. The pharmacologic mechanisms by which minoxidil stimulates hair growth are unknown. This study was designed to examine whether minoxidil has direct effects on neonatal murine epidermal cells in culture. In the presence of minoxidil, cultures showed a marked dose-dependent second peak of DNA synthesis 8-10 days after culture initiation. In addition, two morphologically distinct cell types appeared. Indirect immunofluorescence staining with keratin-specific antibody revealed cytoplasmic keratin fibers, suggesting the epidermal origin of these cells. Our experiments demonstrate that minoxidil can affect epidermal cells in culture by altering their growth pattern and phenotypic appearance [1] . Finite doses of minoxidil (2%, w/v) in formulations containing varying amounts of ethanol, propylene glycol (PG), and water (60:20:20, 80:20:0, and 0:80:20 by volume, respectively) were used. Minoxidil in SC (by tape stripping), appendages (by cyanoacrylate casting), and receptor fluid was determined by liquid scintillation counting. At early times (30 min, 2 h), ethanol-containing formulations (60:20:20 and 80:20:0) caused significantly greater minoxidil retention in SC and appendages, compared to the formulation lacking ethanol (0:80:20). A significant increase in minoxidil receptor penetration occurred with the PG-rich 0:80:20 formulation after 12 h [2]. 作用: 降血压药物,用于顽固性、原发性或肾性高血压。用于预防油脂性脱发及畜牧业。 物理化学性质: CAS号:38304-91-5 常用中文名:米诺地尔 常用英文名:Minoxidil 分子式:C9H15N5O 分子量:209.248 密度:1.5±0.1 g/cm3 沸点:351.7±45.0 °C at 760 mmHg 熔点:272-274 °C (dec.)(lit.) 闪点:166.5±28.7 °C 储存条件:Store at RT |