Rms-07

更新时间：2024-07-17 15:06:26 采购访问：6次

常用名	RMS-07	CAS号	2645409-78-3
价格	$需询单/100mg $需询单/250mg $需询单/1g	纯度	98.0%
备货期	3天	库存	3
产品网页	https://www.dcchemicals.com/product_show-rms-07.html

产品详情（用途，包装等） RMS-07 (RMS 07) is the first potent, selective irreversible covalent inhibitor of Monopolar spindle kinase 1 (MPS1/TTK) with IC50 of 13 nM, Ki of 0.83 nM; demonstrated intracellular target engagement with IC50 of 22.4 nM, shows a high selectivity against MAPKAPK2/3, FGFR4, p70S6Kβ (IC50>1 uM); RMS-07 induced cell cycle arrest with a prolonged G2/M phase, downregulated cyclin B1, whereas it upregulated p53, p21, and phospho-γH2A.X, enhanced cleaved PARP levels; RMS-07 attenuates cancer cell proliferation, RMS-07 and Navitoclax synergistically inhibit hepatocellular carcinoma cell proliferation.

DC Chemicals Limited

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