SB334867
更新时间：2025-08-29 11:37:15
| 常用名 | 1-(2-甲基苯并[D]噁唑-6-基)-3-(1,5-萘啶-4-基)脲 | CAS号 | 792173-99-0 |
|---|---|---|---|
| 价格 | ￥需询单/1kg ￥需询单/1g ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： SB-334867 free base is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2.IC50 value: 7.2 (pKb) [1]Target: orexin OX1 receptor in vitro: SB-334867-A inhibited the orexin-A (10 nM) and orexin-B (100 nM)-induced calcium responses (pK(B)=7.27+/-0.04 and 7.23+/-0.03 respectively, n=8), but had no effect on the UTP (3 microM)-induced calcium response in CHO-OX(1) cells. SB-334867-A (10 microM) also inhibited OX(2) mediated calcium responses (32.7+/-1.9% versus orexin-A) [1].in vivo: Single-unit recordings in anesthetized rats demonstrated the central effects of the selective orexin-1 receptor antagonist SB-334867 (2 mg/kg, intravenous), as it reversed the excitatory effects of orexin-A administration (6 microg, intracerebroventricular) on the activity of locus coeruleus (LC) cells [2]. The ICV injection of SB-334867 alone had no effect on the formalin-induced nociceptive behaviors. Pre-treatment with SB-334867 at a dose of 0.5 nmol significantly attenuated the analgesia induced by morphine (at dose 1.5mg/kg of morphine; interphase and phase 2B and at dose 3mg/kg of morphine just phase 2B of formalin test) [3]. Administered alone, SB-334867 (30 mg/kg, but not lower doses) significantly reduced food intake and most active behaviours (eating, grooming, sniffing, locomotion and rearing), while increasing resting. Pretreatment with SB-334867 dose-dependently blocked these effects of orexin-A, with significant antagonism evident at dose levels (3-10 mg/kg) below those required to produce intrinsic behavioural effects under present test conditions in rats [4].Toxicity: Acute systemic treatment with the selective orexin-1 (OX1R) antagonist SB-334867 reduces food intake in rats, an effect associated with an acceleration in behavioural satiety and unrelated to gross behavioural disruption, alterations in palatability, or toxicity. 物理化学性质： CAS号：792173-99-0 常用中文名：1-(2-甲基苯并[D]噁唑-6-基)-3-(1,5-萘啶-4-基)脲 常用英文名：SB 334867 分子式：C17H13N5O2 分子量：319.317 密度：1.4±0.1 g/cm3 沸点：549.5±58.0 °C at 760 mmHg 熔点：N/A 闪点：286.1±32.3 °C 储存条件：-20℃ |
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：SB-334867
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：SB 334867
- 价格： ￥639.9/5mg ￥830.9/1ml ￥999.9/10mg ￥2199.9/25mg
- 纯度：99.0%
- 备货期：1天
- 联系人：阿拉丁
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1-(2-甲基苯并[D]噁唑-6-基)-3-(1,5-萘啶-4-基)脲生产厂家
参考价格：$92/10mM*1mLinDMSO