ML141
更新时间：2024-01-11 20:10:43
| 常用名 | ML141 | CAS号 | 71203-35-5 |
|---|---|---|---|
| 价格 | ￥需询单/1kg ￥需询单/1g ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： ML141(CID-2950007) is a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase(IC50=200 nM) with low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). IC50 value: 200 nM [1]Target: Cdc42 inhibitorin vitro: In the primary HTS bead-based assay using 1 mM EDTA and 100 nM BODIPY-FL-GTP, potency for CID2950007 was IC50 = 2.6 and 5.4 μM for Cdc42 wild type and activated mutant, respectively [1]. ML141 exposure also enhanced the ability of TMX to suppress BLBC cell growth, through both induction of cell death and suppression of cell division [2]. in vivo: Treatment with ML141 + TMX caused a suppression of further tumour growth in vivo [2]. Parallel suppression of the conserved brain CDC42 activity by intracerebroventricular ML141 injection caused acute anxiety in mice [3]. using a pilocarpine-induced epileptic model, we found that pretreatment with ML141, a specific inhibitor of Cdc42, reduces seizure severity [4]. 物理化学性质： CAS号：71203-35-5 常用中文名：ML141 常用英文名：ML 141 分子式：C22H21N3O3S 分子量：407.485 密度：1.3±0.1 g/cm3 沸点：622.9±65.0 °C at 760 mmHg 熔点：216 °C 闪点：330.5±34.3 °C 储存条件：2-8°C |
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：4-(5-(4-甲氧基苯基)-3-苯基-4,5-二氢-1H-吡唑-1-基)苯磺酰胺
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
- 武汉敬康恩生物医药科技有限公司
- 湖北省 武汉市 东西湖区
- 产品名：ML 141
- 价格： ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：周经理
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参考价格：$92/10mM*1mLinDMSO