NS6180
更新时间：2024-01-28 12:04:22
| 常用名 | NS6180 | CAS号 | 353262-04-1 |
|---|---|---|---|
| 价格 | ￥需询单/1kg ￥需询单/1g ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： NS6180 is a novel potent and selective KCa3.1 channel inhibitor(IC50= 9 nM) prevents T-cell activation and inflammation.IC50 value: 9 nM [1]Target: KCa3.1 channel inhibitorin vitro: NS6180 inhibited cloned human KCa3.1 channels (IC50 = 9 nM) via T250 and V275, the same amino acid residues conferring sensitivity to triarylmethanes such as like TRAM-34. NS6180 inhibited endogenously expressed KCa3.1 channels in human, mouse and rat erythrocytes, with similar potencies (15–20 nM). NS6180 suppressed rat and mouse splenocyte proliferation at submicrolar concentrations and potently inhibited IL-2 and IFN-γ production, while exerting smaller effects on IL-4 and TNF-α and no effect on IL-17 production [1].in vivo: DNBS challenged rats were treated with two doses (3 and 10 mg·kg-1 b.i.d.) of NS6180 for 7 days in direct comparison with the IBD drug sulfasalazine (300 mg·kg-1 q.d.). Both doses of NS6180 significantly improved weight gain and decreased inflammation induced swelling of the colon as determined by relative colon weight [1]. 物理化学性质： CAS号：353262-04-1 常用中文名：NS6180 常用英文名：NS 6180 分子式：C16H12F3NOS 分子量：323.333 密度：1.4±0.1 g/cm3 沸点：476.9±45.0 °C at 760 mmHg 熔点：N/A 闪点：242.2±28.7 °C 储存条件：2-8℃ |
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：NS 6180
- 价格： ￥495.9/10mg ￥5561.9/250mg ￥1853.9/50mg ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
- 上海阿摩尔生物科技有限公司
- 上海市 上海市 奉贤区
- 产品名：4-[[3-(三氟甲基)苯基]甲基]-2H-1,4-苯并噻嗪-3(4H)-酮
- 价格： ￥需询单/100mg ￥需询单/10mg ￥需询单/1g ￥需询单/250mg
- 纯度：99.0%
- 备货期：需询单
- 联系人：王汐瑶
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参考价格：$86/10mM*1mLinDMSO